Latest research on Amlodipine

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.

Latest findings

As long as we believe a self belongs to us, we are each an example of egoism (Dalai Lama, 1995a). [source, 2016]
Personal identity or the self is delusional (Giles, 1993; Joshanloo, 2014); such a self is assumed to not actually exist or not to be permanent (Dalai Lama, 1995b). [source, 2016]
The Dalai Lama (2005) asserted that the term nonself refers to the realization that the self or the I lacks intrinsic existence. [source, 2016]
Buddhist practice traditionally takes place in the context of spiritual development leading to enlightenment in the form of experience of the nonself, a state of total liberation and authentic and durable happiness (Dalai Lama, 1995a,b). [source, 2016]
In fact, it has long been believed and testified to that Buddhist teachings and practices successfully remove pain and suffering, implying that they can be used to deal with all psychological problems (Dalai Lama, 1995a,b, 2005). [source, 2016]
Buddhism's concepts of self, egoism and nonself are complex (Dalai Lama, 1995a; Tsong-Kha-Pa, 2000; Albahari, 2014). [source, 2016]
His regular medications included Irbesartan 150 mg once a day, Amlodipine 5 mg once a day, Simvastatin 20 mg once a day, alfacalcidol 0.25 microgram once a day and Sevelamer 800 mg three times a day with meals. [source, 2016]
However, the results suggested that Ramipril was more effective compared to Amlodipine in slowing decline in GFR. [source, 2016]
The main aim of the study was to compare two treatment regimens; Atenolol and a thiazide (representing the older drugs) vs. Amlodipine and perindopril (the newer classes). [source, 2016]
The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial (35) explored the hypothesis that treatment of hypertensive patients, at a risk of cardiovascular disease was better with a combination of an angiotensin converting enzyme inhibitor (Benazepril) and a Calcium channel blocker (Amlodipine) than a combination of an ACE inhibitor (Benazepril) and a diuretic (Hydrochlorothiazide) as recommended by then prevailing JNC 7 guidelines. [source, 2016]