Latest research on Amphetamine

Amphetamine is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-amphetamine. Amphetamine is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methamphetamine. Amphetamine is a homologue of phenethylamine.

Latest findings

In the present study, we have used PCP and Amphetamine in the paired click paradigm in conscious rats i) to model disturbances in the AEP waveform components observed in schizophrenia and ii) to evaluate the degree to which the mGluR2 agonist LY404039 [48] and the PDE10 inhibitor PQ-10 [51] could improve PCP and Amphetamine-induced auditory processing deficits as was observed with atypical antipsychotics Risperidone and Olanzapine, respectively. [source, 2016]
Treatment groups consisted of challenge drugs such as Amphetamine (0.64 mg/kg) and PCP (3 mg/kg). [source, 2016]
The doses selected for Amphetamine and PCP were repeatedly found to elicit marked alterations in EEG patterns. [source, 2016]
In the first experiments, it was examined whether subcutaneous PCP (3 mg/kg) and Amphetamine (0.64 mg/kg) administration in conscious rats could induce abnormalities in the AEP components and EEG frequency oscillations similr to those described in schizophrenic patients. [source, 2016]
All drugs were synthesized at Janssen Research and Development laboratories and were prepared and administered as follow: Risperidone and Olanzapine (H2O + 2H2T + NaCl, subcutaneous), PCP and Amphetamine (H2O + NaCl, subcutaneous). [source, 2016]
Amphetamine and PCP are widely used to recreate both positive and negative symptoms of schizophrenia in rodents. [source, 2016]
Behavioral abnormalities such as hyperlocomotion and stereotypic behaviors (sniffing, head swaying, rearing) were particularly observed during the first half hour following the administration of Amphetamine and PCP, therefore passive waking epochs in the interval of 40–60 min following the administration were considered here. [source, 2016]
Amphetamine and the NMDA receptor antagonists PCP, KETAMINE and MK801 have repeatedly been used to model schizophrenia-like deficits in sensory encoding and information processing in both humans and animals. [source, 2016]
In the present work, both Amphetamine and PCP disrupted the S2/S1 ratio for P1 and N1 peaks due to reduced suppression of the response to the first stimuli, which is in line with previous reports showing a consistent reduction in both the amplitude to the first stimuli and the gating index [60–62]. [source, 2016]
In accordance with this model, the present work demonstrated that both atypical antipsychotics Risperidone and Olanzapine increased peak amplitudes to S1 stimuli and attenuated Amphetamine and PCP-induced altaerations in AEP peak amplitudes, respectively. [source, 2016]