Latest research on Analgesic

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.

Analgesic side effects

Studies show that Analgesic and anti-inflammatory effect of NSAIDs has been caused by inhibiting cyclooxygenase pathway and subsequently reduce the pain inducing role of arachidonic acid metabolites such as prostaglandin and thromboxane [7]. [source, 2016]
Indomethacin is not routinely prescribed for endodontic treatment but because of its extensive anti-inflammatory effect, it is commonly used to relieve Muscle and Joint pain [15]. [source, 2016]
Despite the previously mentioned efficacy of Indomethacin, Ibuprofen may be a better choice because it is not only a strong Analgesic, but also has fewer side effects compared to Indomethacin [6]. [source, 2016]
The Analgesic effect of NSAIDs is dose-dependent and so are its side effects [6]. [source, 2016]
We next validated the increased rNCX by directly measuring the NCX current (INCX) in Patch clamp experiments. [source, 2016]
Previous studies suggested benefit when combining Propofol with KETAMINE, including reduction in hypotension and respiratory depression secondary to increases in circulatory Norepinephrine induced by KETAMINE, decrease in vomiting and agitation by the antiemetic and anxiolytic properties of Propofol, and reduction in concomitant Analgesic needs. [source, 2016]
When Menthol concentration increased, females displayed a strong aversion and only about 10% of the eggs were laid in the 0.1% Menthol site whereas females rarely laid eggs on 0.5% Menthol. [source, 2016]
The Analgesic dosage was determined the next day at 40 mg Q12h and was increased to 120 mg Q12h after 1 month. [source, 2016]
Later, because the Analgesic effect did not last for 12 hours and the patient refused to take the drug at an incremental dose each time, 600 mg Q8h was attempted. [source, 2016]
Respiratory depression is a life-threatening side effect of opioid drugs, especially when they are used at high doses, when a combination of Analgesic drugs is used, or when high-dose Morphine is intrathecally administered. [source, 2016]