Latest research on Argatroban

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.

Latest findings

Despite intensive conservative therapy including Alprostadil, Argatroban, and sarpogrelate, lower extremity ischemia progressed. [source, 2016]
Patients were excluded from the study i) if they had a prescription of Aspirin as an Analgesic agent during the study period (January 1, 2005 to December 31, 2009), or ii) received low-dose Aspirin before the index period, or iii) had already recorded ischemic heart disease (I20-25) or ischemic stroke (I63) or had been prescribed anti-thrombotic drugs (abcximab, Argatroban, bemiparin, beraprost, Cilostazol, Clopidogrel, dalteparin, Dipyridamole, enoxaparin, fondaparinux, heparin, iloprost, indobufen, lepirudin, limaprost, mesoglycan, nadroparin, ozagrel, reviparin, parnaparin, RH-tissue type plasminogen activator, sarpogrelate, streptokinase, sulodexide, sulfomucopolysaccharide, Tirofiban, Treprostinil, tenecteplase, ticlopidine, Triflusal, urokinase, or warfarin; all the anti-thrombotic drugs covered by the HIRA during the study period) before the index period. [source, 2015]
These included antithrombin III (ATIII; an inhibitor of thrombin and Factor Xa), Argatroban (thrombin inhibitor), and Batroxobin (which depletes fibrinogen). [source, 2015]
Bergamo); RPMI 1640 medium (Biochrom); 200 mM L-Glutamine (Biochrom); aseptically collected FCS (Hyclone Laboratories); thrombin and recombinant urokinase-type Plg activator (uPA; R&D Systems); human plasma Plg-depleted FG, Glu-Plg, tissue Plg activator (tPA), and CRP (EMD Millipore); Cascade Blue trisodium salt and 2′,7′-Bis-(2-Carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF free acid; Invitrogen); Coumarin 314 (Sigma-Aldrich); plasma antithrombin III and Argatroban monohydrate (Sigma-Aldrich); Batroxobin (Pentapharm); recombinant Plg fragments KR1-KR3 (#ab73645; AbCam) and KR3-KR5 (#P00747; Gln274∼Cys560; USCN Life Science Inc.); Factor II/Thrombin, Factor III, Factor VII, Factor XIV, αVβ3, and PAI-1 (R&D Systems); and recombinant human Annexin II (AbD Serotec). [source, 2015]
The patient concomitantly received Argatroban and Aspirin. [source, 2015]
With the help of multiple-choice questions students are instructed to discontinue the heparin infusion instantly and change to the direct thrombin inhibitors Argatroban (as first-line choice) or bivalirudin in patients with hepatic impairment (Coutre et al., 2015). [source, 2015]
Danaparoid, lepirudin, Argatroban, bivalirudin, and fondaparinux are reasonable alternative anticoagulants for treating HIT.[10] [source, 2015]
Argatroban, the first monovalent synthetic thrombin inhibitor to be approved, binds reversibly and competitively to the active site of thrombin. [source, 2015]
According to the manufacturer‘s product information, symptoms of a possible allergic reaction to Argatroban include dyspnea, cough, exanthema (possibly bullous) and general signs of vasodilation. [source, 2015]
However, a causal link to Argatroban has not been possible as yet to conclusively identified. [source, 2015]