Latest research on Aripiprazole

Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.

Aripiprazole interactions

His medication history included fluoxetine, Sertraline, Paroxetine, Escitalopram, Desvenlafaxine, Duloxetine, Levetiracetam, VALPROIC acid, Oxcarbazepine, ezogabine, Aripiprazole, Quetiapine fumarate, Chlorpromazine, Mesoridazine, and Lithium. [source, 2015]
Concerning medication, three patients were free of any antipsychotic medication, the others received mono- or dual therapy with atypical antipsychotic medication including Amisulpride (n = 2), Olanzapine (n = 11), Clozapine (n = 4), Quetiapine (n = 2), Ziprasidone (n = 1), Risperidone (n = 5), Aripiprazole (n = 2), Paliperidone (n = 3; cp. [source, 2016]
Seventy-five patients were taking atypical antipsychotics (Risperidone, Paliperidone, Clozapine, Aripiprazole, Ziprasidone, and/or Quetiapine) at a median Chlorpromazine equivalent dose of 349.20 (277.64) mg/day. [source, 2016]
Data on individual AP drugs are more controversial, with individual phenothiazines and butyrophenones (e.g., Haloperidol) carrying a higher risk as compared with some individual second-generation AP drugs, such as Quetiapine and Olanzapine, which may have a moderate risk, or Aripiprazole, possibly showing a lower potential to cause QTc prolongation [3;4]. [source, 2016]
In addition, we tested whether use of Haloperidol, Risperidone, Olanzapine, Clozapine, Quetiapine, Paliperidone or Aripiprazole was associated with QTc interval. [source, 2016]
In terms of drug treatments, use of Haloperidol, Clozapine, Quetiapine and Aripiprazole was more frequent in patients treated with AP polypharmacy (Table 1). [source, 2016]
Another limitation relates to the small numbers of patients taking some individual drugs, resulting in both limited statistical power to detect associations with QTc interval and unfeasibility to test associations between QTc prolongation and some “classical” AP combinations (e.g. those involving Aripiprazole or Clozapine) recommended by evidence-based guidelines [24]. [source, 2016]
Intramuscular injections of these agents are approved by the FDA for treatment of acute agitation associated with schizophrenia (Aripiprazole, Olanzapine, and Ziprasidone)26–28 and bipolar mania (Olanzapine and Aripiprazole)27,28 and they are now recommended over the first-generation antipsychotics in guidelines.2 [source, 2016]
Orally disintegrating formulations of Olanzapine, Risperidone, and Aripiprazole have been developed, which dissolve with saliva in the mouth and can be swallowed without additional liquid. [source, 2016]
In contrast to the orally disintegrating tablets of Olanzapine, Risperidone, and Aripiprazole, sublingual asenapine is absorbed in the oral Mucosa and peak plasma concentration is reached in 30–60 minutes. [source, 2016]