Latest research on Aspart

Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.

Aspart indications

Udwadia et al. has studied use of IV Insulin Aspart and found it to be safe & effective option for management of hyperglycemia in hospitals [19]. [source, 2015]
In the present study, Insulin Aspart effectively lowered mean blood glucose to target range and was found to be as safe and effective as regular human insulin. [source, 2015]
Use of insulin Aspart by IV route was earlier studied by Robinson et al. in a hyperinsulinemic hypoglycemic clamp study and found that soluble human insulin and insulin Aspart had similar effects upon hypoglycemia-induced alterations in cardiac repolarization [17]. [source, 2015]
Present study has shown IV Insulin Aspart to be safe and effective option for managing perioperative hyperglycemia in patients undergoing cardiac procedure however there was no significant difference in safety profiles of the study insulins. [source, 2015]
Although it is known that there are no advantages of insulin analogs when used intravenously, it will be imperative to have a comprehensive pharmacoeconomic evaluation comparing the cost-effectiveness with use of insulin Aspart as compared to regular human insulin in the hospital settings. [source, 2015]
But the A1Chieve,9 a metacentric non-interventional study on 60000 diabetics in 28 countries, across 4 continents, over 24-weeks, evaluated the safety and effectiveness of Insulin detemir, biphasic insulin Aspart, and insulin Aspart (Novo Nordisk Inc., Plainsboro, NJ, USA), in people with type 2 diabetes mellitus, concluded that starting or switching to insulin analogues was associated with improvement in glycemic control with low frequency of hypoglycemia. [source, 2015]
Some of newer insulin analogs, like insulin lispro, Aspart and detemir also have been upgraded to FDA category B during last 5 years; however, their practical implications and real benefits, remains to be established. [source, 2015]
As well as earlier plasma insulin exposure after injection in people with type 1 diabetes, this insulin produces a significantly greater early glucose‐lowering effect after a test meal than conventional insulin Aspart 92; clamp glucose infusion rates suggest that insulin action continues for ≥4 h. [source, 2015]
In contrast to guidelines previously discussed, the 2007 Institute for Quality and Economic Efficiency in Health Care found the glucose-lowering effect of the GLP-1 Exenatide twice daily to be similar to that of insulin glargine or insulin Aspart, without additional benefit, including benefits to quality of life or treatment satisfaction. [source, 2015]
She maintained insulin therapy using insulin Aspart and insulin detemer without side effects and gave birth to a 3-kg baby via C-section at 37+3 weeks of pregnancy. [source, 2015]