Latest research on Aspart

Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.

Aspart interactions

This trial randomized 1006 patients (3:1) to receive once-daily insulin degludec (100 U/mL; 3 mL) or glargine (100 U/mL; 3 mL), in combination with mealtime insulin Aspart, with or without prescribed Metformin, Pioglitazone or both. [source, 2016]
During hospitalization, patients in CSII alone group received insulin Aspart (NovoRapid, Novo Nordisk, Bagsværd, Denmark) or insulin lispro (Humalog, Eli Lilly, USA) with an insulin pump (MiniMed 712, Medtronic, Northridge, CA) as CSII therapy, while the CSII + Lira group received liraglutide (Victoza, Novo Nordisk, Bagsvaerd, Denmark) 0.6 mg per day in addition to aforementioned CSII regimen. [source, 2016]
Studies of the insulin secretagogues Repaglinide and Glibenclamide, and prandial insulin Aspart have shown increased platelet reactivity,34,35 whereas insulin sensitizers improved platelet reactivity.36,37 [source, 2015]
IV insulin Aspart with Insulin detemir was studied by Dungan et al. to determine whether an insulin algorithm could be used in a similar manner in the setting of diabetes and stress hyperglycemia following cessation of IV (IV) insulin after cardiac surgery and they found use of IV insulin Aspart to be safe in patients after cardiac surgery [26]. [source, 2015]
But the A1Chieve,9 a metacentric non-interventional study on 60000 diabetics in 28 countries, across 4 continents, over 24-weeks, evaluated the safety and effectiveness of Insulin detemir, biphasic insulin Aspart, and insulin Aspart (Novo Nordisk Inc., Plainsboro, NJ, USA), in people with type 2 diabetes mellitus, concluded that starting or switching to insulin analogues was associated with improvement in glycemic control with low frequency of hypoglycemia. [source, 2015]
Physicians would order insulin glargine (Lantus) vials and insulin Aspart (NovoLog) flexpens without specifying doses. [source, 2015]
A study was recently conducted which investigated once-daily insulin degludec versus Insulin detemir, both in combination with bolus insulin Aspart in a 26 week trial, followed by another 26 week extension, in children and adolescents with T1DM. [source, 2015]
The results showed that at 26 weeks, insulin degludec in combination with insulin Aspart was noninferior to Insulin detemir in combination with insulin Aspart. [source, 2015]
Stimulations included: insulin neutral protamine Hagedorn (NPH) (Insuman Basal, Sanofi Aventis, Paris, France), insulin glargine (Lantus, Sanofi Aventis), first metabolite of glargine (M1, Sanofi Aventis), second metabolite of glargine (M2, Sanofi Aventis), glulisine (Apidra, Sanofi Aventis), lispro (Humalog, Eli Lilly, Indianapolis, IN, USA), insulin X10 (not marketed, Novo Nordisk, Bagsvaerd, Denmark), Aspart (B28Asp, Novo Nordisk), detemir (Levemir, Novo Nordisk) and insulin-like growth factor 1 (IGF1) (Increlex, Ipsen, Basking Ridge, NJ, USA). [source, 2015]
He was therefore unwilling to seek or obtain therapeutic HbA1c (below 8%) levels due to his fear of hypoglycemia so that his HbA1c rose to 10.2% in spite of the use of basal/bolus detemir and Aspart insulin therapy along with Metformin and Pioglitazone. [source, 2015]