Latest research on Atomoxetine

Atomoxetine is the first non-stimulant drug approved for the treatment of attention-deficit hyperactivity disorder (ADHD). It is sold in the form of the hydrochloride salt of atomoxetine. This chemical is manufactured and marketed under the brand name Strattera; by Eli Lilly and Company and as a generic Attentin by Torrent Pharmaceuticals. There is currently no generic available within the United States due to patent restrictions. [Wikipedia]

Atomoxetine dosage

Different doses of Dextroamphetamine or Atomoxetine were administered on different days in random order. [source, 2015]
Therefore in order to test specifically for changes in arousal induced by Dextroamphetamine and Atomoxetine, all experiments with Sevoflurane were performed during continuous inhalation of a fixed dose under steady-state conditions. [source, 2015]
With this method, any changes in respiratory drive induced by Dextroamphetamine or Atomoxetine could not account for changes in arousal, since the anesthetic dose remained constant. [source, 2015]
To establish a dose-response relationship, three different doses of Dextroamphetamine and Atomoxetine (0.3 mg/kg, 1 mg/kg, and 3 mg/kg) were administered on different days in random order. [source, 2015]
Therefore, passive emergence after a single IV dose of Propofol can be used to test for arousal changes induced by Dextroamphetamine or Atomoxetine, because changes in respiratory drive will not confound the results. [source, 2015]
Five minutes later, Dextroamphetamine (1 mg/kg IV) or Atomoxetine (3 mg/kg IV) was administered while Sevoflurane anesthesia was maintained at the same dose for 20 additional minutes. [source, 2015]
However, under the same experimental conditions Atomoxetine did not restore righting in any animals (n = 6) during continuous Sevoflurane general anesthesia, even at the highest dose of 3 mg/kg (Fig 1C). [source, 2015]
Forty-five seconds after a single dose of Propofol (8 mg/kg IV), normal saline (vehicle), Dextroamphetamine (1 mg/kg IV) or Atomoxetine (1 mg/kg IV) was administered, and time to emergence was recorded. [source, 2015]
Although it is possible that higher doses of Atomoxetine may have induced behavioral arousal, 3 mg/kg IV is among the highest doses reported in the literature for rats. [source, 2015]
Indeed, this dose of Atomoxetine was high enough to cause significant EEG changes during general anesthesia in the present study, indicating that a sufficient quantity of the drug had reached the brain to induce neurophysiological changes. [source, 2015]