Latest research on Avastin

A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.

Avastin interactions

Three months later, the brainstem glioma increased in size, and his chemotherapy was changed to Avastin and Irinotecan, with no further radiographic or clinical progression, now 18 months later. [source, 2016]
Recently, some antiangiogenic drugs including Thalidomide, Avastin, and endostatin have been approved by Food and Drug Administration (FDA) to use in chemotherapy (12). [source, 2015]
Expecting continued success, the Avastin in Gastric Cancer (AVAGAST) trial for evaluating the efficacy of additional bevacizumab to chemotherapy (Capecitabine and Cisplatin) as the first-line treatment for unresectable AGC was conducted. [source, 2015]
Neovascular AMD is currently treated with regular intravitreal injections of anti-VEGF agents, including ranibizumab (Lucentis, Genentech, San Francisco, CA), bevacizumab (Avastin, Roche, Basel, Switzerland) and more recently aflibercept (Eylea, Regeneron, Tarrytown, New York). [source, 2015]
The search for unpublished RCTs or those in progress was from their metaRegister of Controlled Trials [38] using the following search terms: monoclonal antibodies; mAb; anti-VEGF; anti-EGRF; bevacizumab OR, Avastin OR. panitumumab OR. Vectibix cetuximab OR. Erbitux OR. colorectal neoplasms OR. colorectal cancer OR. colorectal carcinomas. [source, 2015]
The following terms were used for the searches: (“polypoidal choroidal vasculopathy” OR PCV) AND (“angiogenesis inhibitors” OR “endothelial growth factors” OR VEGF OR Lucentis OR ranibizumab OR bevacizumab OR Avastin) AND (“photodynamic therapy” OR PDT). [source, 2015]
The annual sales of the top-selling antibody drugs, such as Humira, Remicade, Avastin, Rituxan and Herceptin, are over or close to $ 10 billion now while many potential blockbusters are being investigated in clinical trials [1, 2]. [source, 2015]
Five top-selling therapeutic antibodies which are also popular biosimilar candidates for many biotech companies, namely Herceptin (trastuzumab), Avastin (bevacizumab), Remicade (infliximab), Rituxan (rituximab) and Humira (adalimumab), were used as model molecules in this study. [source, 2015]
The optimized signal peptides for Herceptin, Avastin, Remicade, Rituxan and Humira were identified. [source, 2015]
The variable regions and the constant regions of the HC and LC of Herceptin, Avastin, Remicade, Rituxan and Humira were generated based on publicly available information. [source, 2015]