Latest research on Azathioprine

An immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis.

Latest findings

In view of the high positive predictive value of TPMT genotyping and the potentially life-threatening adverse drug events associated with the TPMT poor metabolizer phenotype, it is difficult to explain the number of PGx experts who decided to prescribe Azathioprine at normal dosage in scenario 1. [source, 2016]
Others include corticosteroids, Azathioprine, mercaptopurines and Cyclosporine, which are used for more severe forms of the disease [12]. [source, 2016]
During the entire study period, loperamide or anti-inflammatory drugs, such as oral, rectal or intravenous corticosteroids, and immunosuppressants such as Azathioprine, 6-Mercaptopurine, methotrexate, Cyclosporine or anti-TNF-α were not permitted. [source, 2016]
In these analyses, medication costs were assessed and include any of the eight groups of prescription medications used to possibly treat IPF (corticosteroids, Azathioprine, Cyclophosphamide, N-acetylcysteine, Sildenafil, interferon-gamma, bosentan, etanercept). [source, 2016]
Other Disease-Modifying Antirheumatic Drugs (DMARDs) like Leflunomide, Cyclosporine, and Azathioprine were infrequently used and they were not included. [source, 2016]
Steroids were gradually tapered over a 3-month duration and the treatment was maintained with low-dose steroids and Azathioprine (1.5-2 mg/kg/day). [source, 2016]
Prior immunosuppressant therapies that were most commonly given to 68 patients who developed natalizumab-related PML included (some patients received more than one agent): Mitoxantrone (38/68 (55.9%) confirmed PML cases), Cyclophosphamide (14/68 (20.6%) confirmed PML cases), Azathioprine (11/68 (16.2%) confirmed PML cases), methotrexate (9/68 (13.2%) confirmed PML cases), Mycophenolate mofetil (6/68 (8.8%) confirmed PML cases), and other immunosuppressants (8/68 (11.8%) confirmed PML cases). [source, 2016]
Corticosteroids induce T lymphocyte apoptosis, and other agents such as Azathioprine also inhibit cell proliferation [26]. [source, 2016]
However, and perhaps more importantly, a treatment option, in the form of triple therapy with low dose Prednisolone, Azathioprine, and N-acetyl cysteine [6], was available. [source, 2016]
Any other drugs, like Sulfasalazine, Azathioprine, and anti-TNF-α therapy, and smoking were stopped as soon as the patient was hospitalized. [source, 2016]