Latest research on Betamethasone

A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)

Latest findings

Subsequent randomized controlled trials, which demonstrated reduced perinatal mortality and morbidity, particularly respiratory distress syndrome, led to a change in antenatal care, and antenatal Betamethasone therapy has become a standard of care in the majority of medical centers worldwide [6, 7]. [source, 2016]
The currently accepted dosage of Betamethasone was determined by Liggins and Howie in the 1970s; since that time, pregnant women at risk for preterm birth have been administered a fixed dosage of Betamethasone, regardless of gestational age, maternal body mass index, and the presence of a singleton or multiple gestation [8]. [source, 2016]
Although Betamethasone treatment reduces mortality and morbidity in general [9], its effect for a particular woman may be unpredictable, and varying outcomes between two preterm neonates with similar obstetrical background born at a similar gestational age after treatment with Betamethasone may often be observed. [source, 2016]
Moreover, among multiple pregnancies, the benefit of Betamethasone is uncertain [10, 11]. [source, 2016]
For that reason the optimal dosage for Betamethasone in terms of benefit and safety is still unknown. [source, 2016]
To the best of our knowledge, the relationship between Betamethasone concentration and perinatal outcome has not been reported. [source, 2016]
In part, this may be due to an absence of a reliable method for measuring serum Betamethasone concentrations. [source, 2016]
In view of that, we aimed in this study to assess the ability of a specific ELISA kit to measure the concentrations of Betamethasone in maternal serum and to examine the trend of sequential measurements in maternal serum after a Complete course of Betamethasone for lung maturity. [source, 2016]
Betamethasone concentration in samples was determined using the Corticosteroid ELISA kit (Randox Laboratories Ltd. [source, 2016]
Those parameters were analyzed by spiking Betamethasone (provided with the kit) and the same generic Betamethasone that was administered to women into a pool of human sera. [source, 2016]