Latest research on LEA29Y

Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. It is approved for the treatment of rheumatoid arthritis. Belatacept selectively blocks the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids. FDA approved on June 15, 2011.

LEA29Y dosage

In vitro, FR104 and CTLA4-Ig (LEA29Y) dose-dependently prevented human T cell proliferation to a similar extent in mixed lymphocytes reactions with EC50 at 0.16 and 0.18 micrograms/ml, respectively. [source, 2012]
Previous transplantation studies in rats and nonhuman primates using high doses of belatacept for systemic immunosuppression also have shown that costimulatory blockade by LEA29Y does not exert any adverse effects on β-cell function (5,11). [source, 2012]
In a dose ranging pilot study of patients with active RA [2], both abatacept and LEA29Y produced dose dependent reductions in the clinical manifestations of disease. [source, 2005]
A total of 90 received abatacept at doses of 0.5 mg/kg, 2 mg/kg, and 10 mg/kg; 92 received LEA29Y at the same doses; and 32 received placebo infusions. [source, 2005]