Latest research on Calcium

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.

Latest findings

Based on a clinical study phase 2, we prescribed him six cycles of the 120 mg denosumab subcutaneously monthly, with a daily ingestion of the 400 IU Vitamin D and 1 g Calcium. [source, 2016]
Transfections were performed using the Calcium phosphate transfection method using BES buffer [140 mM NaCl, 0.75 mM sodium phosphate dibasic (Na2HPO4), 25 mM N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), pH 6.95]. [source, 2016]
Stone analysis demonstrated clearly that Calcium oxalate was the most prevalent stone composition in both groups (Amplatz PCNL: 82%; MTD PCNL: 86%). [source, 2016]
TZ cells are highly sensitive to touch and extracellular Calcium (Ishikawa and Evans, 1992; Baluška et al., 1996), aluminum (Marciano et al., 2010; Sivaguru et al., 2013; Yang et al., 2014), osmotic stress (Baluška and Mancuso, 2013), auxin (Mugnai et al., 2014) and gravity (Masi et al., 2015). [source, 2016]
Factors contributing to VC include age, comorbidity (diabetes, hypertension, metabolic syndrome, dyslipidemia), dialysis vintage, medications (Calcium, Vitamin D, Coumadin), and uremia-related mineral bone disorder (serum Calcium [Ca], phosphorus [P], Parathyroid hormone [PTH]) 11-15. [source, 2016]
Regression adjusted for age, HD vintage, vascular disease, BMI, waist circumference, Kt/V, parameters of mineral-bone disorder (serum Calcium [Ca], phosphorus [P] and intact Parathyroid hormone [iPTH]), gelsolin and IL-6. [source, 2016]
At baseline, the subjects with and without AAC had similar dialysis adequacy (Kt/V 1.38 ± 0.22 vs. 1.45 ± 0.23, P>0.05) and biochemical control, particularly serum Calcium (9.2 ± 0.8 vs. 9.4 ± 0.9 mg/dL, P>0.05) and phosphate (4.8 ± 1.4 vs. 4.9 ± 1.4 mg/dL, P>0.05). [source, 2016]
Multiple logistic regression (adjusting for age, HD vintage, vascular disease, BMI, waist circumference, Kt/V, serum Calcium, phosphorus, iPTH, gelsolin and IL-6) confirmed baseline gelsolin and waist circumference as the independent factors associated with progressive AAC (Table 2). [source, 2016]
Acute application of IGF-1 or its analog des-IGF-1 have been reported to potentiate excitatory synaptic transmission through either presynaptic (Xing et al., 2007) or postsynaptic (Ramsey et al., 2005) mechanisms, to modulate voltage-gated Calcium channels (VGCCs) (Blair and Marshall, 1997), and to increase intrinsic neuronal excitability (Wang et al. [source, 2016]
The intracellular cycle of T. gondii also depends on host cell factors, and some kinase inhibitors, such as wortmannin, staurosporine, and genistein, which block PI3K, PKC, and TYROSINE kinase activities, respectively, have been known to inhibit Calcium ionophore A23817-induced invasion and egress at early stages of infection [22-24]. [source, 2016]