Latest research on Ceftaroline

Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.

Latest findings

According to the guideline recommendations, empiric intravenous (IV) Antimicrobial agents for the treatment of suspected severe MRSA ABSSSIs include Vancomycin, Daptomycin, Linezolid, telavancin, or Ceftaroline. [source, 2016]
Ceftaroline is a broad-spectrum cephalosporin Antimicrobial with extended gram-positive bacteria coverage. [source, 2016]
Ceftaroline provides an important new treatment option that may help overcome some of the current challenges we face when managing patients with MRSA infections. [source, 2016]
In this study, we investigated the effects of subinhibitory concentrations of Ceftaroline on biofilm formation by MRSA strains. [source, 2016]
All the clinical strains tested were susceptible to Ceftaroline, with MICs ranging 0.25–0.5 μg/ml. [source, 2016]
Electron micrographs taken after 48h exposure to Ceftaroline showed breaks in the walls of several cells and ghosts of lysed cells. [source, 2016]
The morphological changes triggered by Ceftaroline are in agreement with the PBP binding affinities of this Antibiotic and these images represent a visual record of the bactericidal effect of Ceftaroline. [source, 2016]
Interestingly enough is our observation of non-dividing cells in strain 05/3291 treated with Ceftaroline, which are mainly broken (but not deformed) at the site where the peripheral wall ring leads to daughter cell separation in S. aureus (Fig 1 and S2 Fig). [source, 2016]
Ceftaroline affected the biofilm formation of all strains tested at MIC, and in one strain (05/2369) at all concentrations tested. [source, 2016]
Importantly, at lower sub-MICs of Ceftaroline (from 1/4 to 1/16) the biofilm growth of two MRSA and the MSSA isolate was not affected. [source, 2016]