Latest research on Celecoxib

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form.

Latest findings

Astaxanthin and Celebrex (another COX2 inhibitor) work cooperatively for some diseases, which therefore were suggested to be taken both together to alleviate oxidative-damage [72]. [source, 2016]
To determine if inflammation is necessary for stress to modulate lymphatic architecture and lymphogenous spread, we treated control and stressed mice bearing MDA-MB-231 mammary tumours with the COX2 inhibitor Celecoxib. [source, 2016]
For COX2 inhibitor studies, mice received Celecoxib (Celebrex; Clifford Hallam; 25 mg kg−1 day−1) in drinking water. [source, 2016]
When mouse were treated with anti-inflammation Celecoxib, the tumor mass was decreased and their life expectancy increased from 28 to 49 days. [source, 2016]
Specifically, Celecoxib and rofecoxib treatment decreases the deposition of Aβ1–42 in AD patients and mouse models4950. [source, 2016]
To verify the accuracy of the employed docking methods, we first selected four known inhibitors for these enzymes (Physostigmine, Indinavir, epalrestat and Celecoxib, Fig. 1) as reference molecules. [source, 2016]
Lastly, Celecoxib (CELEBREX™) was from Phamacia (Northumberland, UK). [source, 2016]
The indicated doses of vehicle (acetone, 200 μL/site), Tat-SOD, Celecoxib, or PTIO were topically administered to the shaven back of a mouse for 2 h, and then it was further treated with TPA (10 nmol/200 μL/site) [33] or SNP (20 μmol/200 μL/site) for 4 h. [source, 2016]
Tat-SOD solution was topically administered to the shaven backs of mice with Celecoxib (a COX-2 inhibitor) or PTIO (an SNP antagonist) for 30 min; then, animals were treated with SNP (an NO donor) for 4 h to test the protective effect. [source, 2016]
The pigment tone was significantly and dose-dependently attenuated by Tat-SOD and Celecoxib, indicating that Tat-SOD effectively reduced SNP-induced COX-2 production as well as did Celecoxib in mouse skin. [source, 2016]