Latest research on Celecoxib

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form.

Celecoxib interactions

To verify the accuracy of the employed docking methods, we first selected four known inhibitors for these enzymes (Physostigmine, Indinavir, epalrestat and Celecoxib, Fig. 1) as reference molecules. [source, 2016]
mice with inhibitors that block both COX1 and COX2 (Indomethacin) and COX2 alone (Celecoxib) abrogates mortality induced by the lethal dose of TsV. [source, 2016]
Similar results were observed in C57BL/6 mice injected with a lethal dose of TsV and treated with Indomethacin, Celecoxib or an EP2 antagonist, AH6809. [source, 2016]
Although ∼50–70% of C57BL/6 mice died after administration of 180 μg kg−1 TsV, Indomethacin, Celecoxib and EP2 antagonist treatment decreased mortality, PGE2 and IL-1β production and neutrophil infiltration in the lungs (Fig. 4b–d). [source, 2016]
In a specific experiment, the mice were either treated or not treated with MK886 (5-LO inhibitor, 5 mg kg−1 i.p., in 200 μl of 1% alcohol in water)64, Indomethacin (COX1/2 inhibitor, 2 mg kg−1 i.p. in 200 μl of Tris[hydroxymethyl]aminomethane-HCl; TRIS-HCl, pH 8.2)65, SC-560 (selective COX1 inhibitor, 3 mg kg−1 i.p., in 200 μl of PBS, Sigma-Aldrich)66, Celecoxib (COX2 inhibitor, 5 mg kg−1 i.p., in 200 μl of water)64 or EP2 antagonist (AH6809, 5 mg kg−1 i.p., in 200 μl of PBS, Cayman Chemical)67. [source, 2016]
To Maintain the blind (among patients, physicians, site staff and contract research organisation), Celecoxib capsules were overencapsulated and placebo capsules had an identical appearance to the combination product. [source, 2016]
The patient was started on 6-Mercaptopurine and Celecoxib for the treatment of an AInD, with resolution of the symptoms of fever and arthralgia. [source, 2016]
Such an approach was used in Case 1, in which a patient with underlying CD was managed with 6-Mercaptopurine as well as the cyclooxygenase 2-selective anti-inflammatory medication Celecoxib. [source, 2016]
We have also reported that, in vitro, the anti-inflammatory drug, Celecoxib, can specifically induce EC AMPK phosphorylation,34 while at supra-therapeutic concentrations, Metformin has a similar effect. [source, 2016]
Both patients initiated immediate treatment with ETORICOXIB selective COX-2 (Celebrex 200 mg, Tauxib 90 mg) for 2 months and, after an initial period of immobility of around ten days to allow proper healing of the wound, were subjected to intense rehabilitation treatment and the use of splinting in alternating maximum pronation or supination positions, in order to restore the full range of movement (Figure 6). [source, 2016]