Latest research on Welchol

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.

Welchol dosage

To further determine whether the increased FGF15 level is an underlying mediator, DIO mice treated with or without FGFR4 ASO plus Welchol were infused continually with recombinant, biologically active FGF19 at a dose of 100 ng/kg/day for 7 days. [source, 2013]
In a study of 16 healthy volunteers administered colesevelam HCl 1.9 g twice a day for 28 days, an average of only 0.05% of a single 14C-labeled colesevelam HCl dose was excreted in the urine (Welchol) supporting its limited systemic uptake. [source, 2007]