Latest research on Welchol

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.

Welchol side effects

The study was repeated in DIO mice treated with FGFR4 ASO #1 at 50 mg/kg /week and fed the 58% HF diet mixed with 2% Welchol, a bile acid sequestrant; the latter was used to eliminate FGFR4 reduction caused increase in plasma FGF15 levels. [source, 2013]
To further determine whether the increased FGF15 level is an underlying mediator, DIO mice treated with or without FGFR4 ASO plus Welchol were infused continually with recombinant, biologically active FGF19 at a dose of 100 ng/kg/day for 7 days. [source, 2013]
FGF19, but not saline, caused significant increases in VO2 (Figure 7D) and whole body heat production as well (Figure 7E) during infusion in the mice without FGFR4 ASO treatment or with FGFR4 ASO treatment plus Welchol feeding. [source, 2013]
A practical example is the use of colesevelam HCl with thyroid hormone, in that post marketing reports have suggested increases in Thyroid stimulating hormone (TSH) levels in patients who have received colesevelam HCl co-administered with thyroid hormone replacement therapy (Welchol). [source, 2007]
According to the prescribing information for colesevelam HCl (Welchol), when compared to placebo in an integrated safety analysis, the treatment-emergent adverse experiences that occurred in greater than 2% did not increase with colesevelam HCl with regard to “Body as a Whole” or “Respiratory System”. [source, 2007]