Latest research on Cialis

Tadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy. [Wikipedia]

Latest findings

We expected to discover some compounds from nature products that would have higher activities than that of Viagra and Cialis. [source, 2009]
Of the men who reported seeking assistance for erectile function, 383 (77.5%) stated that they used a phosphodiesterase type 5 inhibitor (for example, sildenafil, tadalafil, or vardenafil (Viagra, Cialis, and Levitra, respectively)), although 168 (43.9%) of these individuals stated that such agents were of “little or no use. [source, 2009]
Tadalafil (Cialis) is a potent reversible phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction. [source, 2009]
Reported PDE5 inhibitors can be divided into the following classes: 1) cGMP-based, represented by sildenafil (Viagra) and vardenafil (Levitra) (Pfizer, Bayer, Sheering-Plough), 2) β-carboline – derived, represented by tadalafil (Cialis) (Lilly, Johnson&Johnson [J&J], 3) quinazoline and isoquinolinone derivatives (Bristol-Myers-Squibb [BMS], Japan), and 4) phthalazine derivatives (BMS, Japan). [source, 2008]
Tadalafil was officially born in the year 2000 when a new drug application was put forth for IC351 with the generic name tadalafil and trade name Cialis. [source, 2008]
Recently, more highly selective PDE5 inhibitors have been developed mainly for the treatment of erection disorder, e.g., sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) (Setter et al. 2005). [source, 2008]
Today, the first-line oral pharmacotherapy for most patients with erectile dysfunction is a PDE 5 inhibitor: sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) (Briganti et al 2005; Boswell-Smith, Spina, et al 2006). [source, 2007]
The pharmaceutical industry has recently discovered this market, which has resulted in the development of popular erectile dysfunction medications such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) (Figure 1). [source, 2007]
The annual revenues generated by sales of Viagra and Cialis were respectively over $1 billion and $747 million in 2005 [27,28]. [source, 2007]
For in vivo studies, tadalafil (Cialis, Eli Lilly & Company) was administered in vivo by oral gavage at a dose of 1 mg/kg and was prepared as previously described [17]. [source, 2015]