Latest research on Copaxone

Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis

Copaxone side effects

Data suggests that studies with follow-ups of a week (7 days) or shorter will probably not be able to observe the increase in neurogenesis and the resultant functional improvement due to immunization with COP-1. [source, 2015]
This data suggests that the increased neurogenesis seen in the COP-1 cohort during the acute phase after tMCAo can be mediated—at least to a certain extent—by an increased production of NT-3. [source, 2015]
Treatment with COP-1 significantly increased the number of new neurons 60 days after tMCAo (Fig 6A COP-1 vs. Vehicle: 14.3 ± 3.9 vs. 4.0 ± 1.4; P < 0.05). [source, 2015]
Moreover, we have added the assertion that COP-1 increases neurogenesis in the ipsilateral SVZ, SGZ and the CC. [source, 2015]
At both time points, COP-1 immunization was capable of inducing a significant increase in neurogenesis. [source, 2015]
Data from two arrays—one replicate of Copaxone lot X06841 and one media-only sample—were excluded from analysis because of poor array quality. [source, 2015]
Copaxone produced a dose-dependent increase in IL-4 release from these Th2-polarized T cells (Fig 2B); a similar dose effect was seen with the other cytokines (data not shown). [source, 2015]
Furthermore, the less conservative approach based on permutation testing also indicated significance (P = 0.024) when comparing Copaxone and ACN, thereby suggesting that these differences were not caused by random chance. [source, 2015]
Copolymer-1, another MS drug that serves as a myelin decoy, showed anti-inflammatory benefits in an HIVE mouse model, with decreased pro-inflammatory cytokine and iNOS expression, coupled with increased BDNF levels. [source, 2015]
CO was still released from the cyclodextrin formulated compounds, as demonstrated by a time dependent increase in fluorescence intensity when COP-1 was incubated with [email protected] and [email protected] in the presence of pig liver esterase or lysates of HUVEC as the esterase source (Fig. 2a). [source, 2014]