Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis
Furthermore, because codelivery of both antigen and a secondary “context” signal through separate homopolymers was effective at treating EAE, this therapeutic paradigm may ultimately be adaptable as a supplemental additive formulation to current antigen only therapeutics such as Copaxone
(R) (myelin antigen derivative) and therapeutics such as Tysabri
(R) (surface receptor) inhibitor.
One Internet report, connected to the FDA adverse events reporting database, stated that, of 9,277 patients who reported to have side effects while taking Copaxone
, 3 experienced eosinophilia (0.03%) .