Latest research on Cortisol

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]

Latest findings

MCF10A cells were cultured as described (32) in DME:F12 medium (Gibco BRL, Grand Island, NY, USA) supplemented with 10 μg ml−1 insulin, 0.1 μg ml−1 cholera toxin, 0.5 μg ml−1 Hydrocortisone, 5% heat-inactivated Horse serum (Biological Industries, Beit-Haemek, Israel) and 10 ng ml−1 EGF. [source, 2016]
In humans, the major hormones of the HPA axis are corticotrophin releasing factor (CRF), adrenal corticotrophin hormone (ACTH), and Cortisol. [source, 2016]
CRF is transported to the anterior pituitary and stimulates the release of ACTH, which in turn stimulates the synthesis and release of Cortisol by the adrenal cortex to prepare the body for coping with stress. [source, 2016]
Cortisol in blood binds to brain receptors in the amygdala, prefrontal cortex and hippocampus. [source, 2016]
Hence, the Cortisol stress response may demarcate individual differences in functioning associated with these areas. [source, 2016]
Two neurobiological theories link the Cortisol stress response to risk-taking behaviour [48]. [source, 2016]
Previous studies have found blunted Cortisol stress responses in different RD samples [49–51], however comparative examination of Cortisol stress response related to different forms of RD has been lacking. [source, 2016]
Mean baseline Cortisol levels and Cortisol stress responses are summarized in Table 3. [source, 2016]
Repeated measures ANCOVA of the three baseline Cortisol intervals, with group the between factor, and ethnic background the covariate, did not detect a significant effect of group nor a group by time interaction. [source, 2016]
Preliminary diagnostic analyses on Cortisol stress response revealed one outlier (DWI), which was transformed. [source, 2016]