Latest research on Cyclosporine

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Latest findings

Ultimately, a combination of topical Fluticasone, Cyclosporine, Acitretin, oral Prednisone, and intramuscular methotrexate yielded mild to moderate improvement for periods of time. [source, 2016]
The administration of topical Fluticasone, Cyclosporine, and oral methotrexate were continued, under the presumed diagnosis of atopic dermatitis. [source, 2016]
Others include corticosteroids, Azathioprine, mercaptopurines and Cyclosporine, which are used for more severe forms of the disease [12]. [source, 2016]
During the entire study period, loperamide or anti-inflammatory drugs, such as oral, rectal or intravenous corticosteroids, and immunosuppressants such as Azathioprine, 6-Mercaptopurine, methotrexate, Cyclosporine or anti-TNF-α were not permitted. [source, 2016]
Cyclosporine A (CsA) can prevent this mitochondrial permeability transition and the subsequent apoptosis [22]. [source, 2016]
In another study Cyclosporin A has been used in infected RT recipients [41]. [source, 2016]
Other Disease-Modifying Antirheumatic Drugs (DMARDs) like Leflunomide, Cyclosporine, and Azathioprine were infrequently used and they were not included. [source, 2016]
The third published case of rhabdomyolysis was described 1 week post influenza vaccination in a 57 year old renal transplant patient on Simvastatin and Cyclosporin A [21]. [source, 2016]
N-acetyl-para-aminophenol (APAP), capsazepine (CPZ), 2-aminoethyl diphenylborinate (2-APB), Clotrimazole (CTZ), 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-p-benzoquinone (AA861), N-ACETYL-L-cysteine (NAC), dimethylfumarate (DMF), metaphosphoric acid, triethanolamine, and Cyclosporine A (CsA) were from Sigma-Aldrich (St. Louis, MO, USA). [source, 2016]
For these experiments, we employed the specific inhibitors W-7 for Ca2+-calmodulin, Cyclosporine A (CsA) for MPT, U0126 for ERK, SP600125 for JNK, and SB203580 for P38 MAPK. [source, 2016]