Latest research on Danazol

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. [PubChem]

Latest findings

These orphan drugs are Imiglucerase, sapropterin dihydrochloride, recombinant coagulation Factor VIII, coagulation factor VIIa, human coagulation Factor VIII, human prothrombin complex concentrate, bosentan, Iloprost, ambrisentan, recombinant human Growth hormone, Busulfan, teniposide, Mitoxantrone, Imatinib, Dasatinib, nilotinib, meisoindigo, Arsenious Acid, homoharringtonine, rituximab, sorafenib, Danazol, Riluzole and poractant alfa. [source, 2016]
There are five orphan drugs defined as DDD by WHO, including Imiglucerase 300U, bosentan 250 mg, iloprost 50 ug, Danazol 600 mg, Riluzole 100 mg [20]. [source, 2016]
Endometriosis treatments include surgical resection and the consumption of estrogen inhibitors, such as aromatase inhibitors, Danazol, oral contraceptive pill, progestins, GnRH agonists, progesterone antagonists, and selective estrogen modulator receptors[ [source, 2016]
Danazol, a synthetic androgen, is a derivative of 17α-ethinyltestosterone that is usually used as a treatment option for endometriosis [109]. [source, 2016]
Danazol can induce a hypoestrogenic, as well as, a hypoandrogenic state in the uterus, resulting in atrophy of the endometrium [110111]. [source, 2016]
Various studies have shown the significant effects of Danazol against EH [112113114115116]. [source, 2016]
Danazol containing IUDs (D-IUDs) might also be a novel and effective method for the treatment of EH [117]. [source, 2016]
However, some studies have suggested that Danazol can increase the risk of ovarian cancer among women with endometriosis [118]. [source, 2016]
Other side effects of Danazol include weight gain, muscle cramps, acne, seborrhea, decreased breast size, hirsutism, and deepening of the voice, which are all strongly related to androgenic action [119]. [source, 2016]
Available therapeutic options for EH, such as progestin, Danazol, genistein, Metformin and GnRH therapy or surgery have restricted efficacy due to high cost, side effects and drug resistance. [source, 2016]