Latest research on Daptomycin

Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium Streptomyces roseosporus. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.

Latest findings

According to the guideline recommendations, empiric intravenous (IV) Antimicrobial agents for the treatment of suspected severe MRSA ABSSSIs include Vancomycin, Daptomycin, Linezolid, telavancin, or Ceftaroline. [source, 2016]
Results obtained by Barber et al., using Ceftaroline combinations (Daptomycin or Vancomycin) are leading in the same direction [44]. [source, 2016]
Daptomycin is a novel cyclic lipopeptide Antibiotic secreted by Streptomyces roseosporus. [source, 2016]
Daptomycin has excellent activity against Gram-positive bacteria through disruption of multiple bacterial plasma membrane functions, without penetrating the cytoplasm [11]. [source, 2016]
Clinical experience with Daptomycin treatment of PJI is limited to systemic intravenous use in small case series [12–14]. [source, 2016]
Several in vitro studies also showed that Daptomycin could be locally delivered from PMMA bone cement without impairing cement strength [15, 16]. [source, 2016]
Only one clinical report showed combined use of Daptomycin in bone cement and intravenously to treat chronic PJI in a 2-stage surgery [17]. [source, 2016]
The aim of this study was to review the results of Daptomycin used in PMMA bone cement and systemically in 2-stage exchange surgeries for the treatment of PJI due to methicillin-resistant Staphylococcus species. [source, 2016]
Consecutive adults who underwent 2-stage revision arthroplasty using local and systemic Daptomycin for the treatment of PJI caused by methicillin-resistant Staphylococcus species were included. [source, 2016]
The use of local and systemic Daptomycin for the treatment of methicillin-resistant Staphylococcus PJI was just done during the study period. [source, 2016]