Latest research on Daptomycin

Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium Streptomyces roseosporus. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.

Daptomycin dosage

If the methicillin-resistant microorganism had been identified at the time of resection arthroplasty, the dose of Daptomycin was 4 g per 40 g package of bone cement (Stryker Orthopaedics, Mahwah, New Jersey) to reach therapeutic levels in the joint fluid [20]. [source, 2016]
The actual dosage of Daptomycin added in the bone cement as a spacer to treat PJI is unclear. [source, 2016]
Therefore, we thought higher dose Daptomycin (10 % w/w) in PMMA bone cement to reach local therapeutic levels for the treatment of PJI due to methicillin-resistant Staphylococcus species. [source, 2016]
In another study, severe side effects (one case of acute renal failure due to massive rhabdomyolysis, one of eosinophilic pneumonia and 2 cases of asymptomatic transient CPK level elevation) were also reported with Daptomycin at a dose of 6.6 mg/kg/day for an average of 44.9 days in the treatment of PJI [13]. [source, 2016]
Because of further increased inflammation markers and clinical deterioration, the anti-infective therapy was supplemented by Levofloxacin (2 × 500 mg/d) and Daptomycin (1000 mg loading-dose, 500 mg/d) for the coverage of methicillin-sensitive S. aureus and atypical pathogens two days after hospital admission. [source, 2015]
However, only one study was found in the literature in which an analytical method for the analysis of Daptomycin in the pharmaceutical dosage form using HPLC was described [35]. [source, 2015]
Considering the importance of Daptomycin for the global scene and the lack of literature concerning microbiological methods for the analysis of this Antimicrobial, the aim of this work was to propose a rapid turbidimetric method for the analysis of the potency of Daptomycin in the dosage form of powder for injectable solution. [source, 2015]
In order to statistically compare the proposed microbiological method with the previously validated HPLC method, six determinations of Daptomycin in the pharmaceutical dosage form were performed using both methods. [source, 2015]
A comparison between the developed turbidimetric method with a HPLC method previously developed and validated by our group was performed in order to verify whether these two methods are interchangeable for the analysis of Daptomycin in the pharmaceutical dosage form. [source, 2015]
A microbiological method has been properly developed and validated and shown to be effective for determining the potency of Daptomycin in the pharmaceutical dosage form of lyophilized powder for injectable solution, since it was linear, precise, accurate, robust and selective. [source, 2015]