Latest research on Daptomycin

Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium Streptomyces roseosporus. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.

Daptomycin interactions

According to the guideline recommendations, empiric intravenous (IV) Antimicrobial agents for the treatment of suspected severe MRSA ABSSSIs include Vancomycin, Daptomycin, Linezolid, telavancin, or Ceftaroline. [source, 2016]
Results obtained by Barber et al., using Ceftaroline combinations (Daptomycin or Vancomycin) are leading in the same direction [44]. [source, 2016]
Daptomycin is a novel cyclic lipopeptide Antibiotic secreted by Streptomyces roseosporus. [source, 2016]
If the infecting microorganism could not be identified preoperatively, a combination of 4 g of Daptomycin and 4 g of Ceftazidime (10 % w/w for each Antibiotic) per 40 g package of bone cement was used. [source, 2016]
After prophylaxis with intravenous 1 g Vancomycin, the patients underwent prosthesis reimplantation with 1 g Daptomycin (2.5 % w/w) in a pack of 40 g bone cement [Stryker Orthopaedics, Mahwah, New Jersey] without decreasing the cement strength [15, 16] for knee or hip prosthesis fixation. [source, 2016]
For knee implantation, we usually use 1 g Daptomycin in a pack of 40 g bone cement for tibia and patellar component fixation and 1 g Vancomycin in another pack of bone cement for femoral component fixation. [source, 2016]
Hall et al. showed that Daptomycin could be released from PMMA cement at a rate similar to that of Vancomycin in vitro study [27]. [source, 2016]
The efficacy of Daptomycin against Staphylococci, compared to Vancomycin, has been demonstrated in vivo and in vitro studies. [source, 2016]
Daptomycin had a higher bactericidal rate than Vancomycin (92 % vs. 70 %) in an in vitro study [28]. [source, 2016]
Daptomycin showed greater and more rapid bactericidal activity than Vancomycin in mice infected by MRSA [29]. [source, 2016]