Latest research on Daptomycin

Daptomycin is a lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is a naturally-occurring compound found in the soil bacterium Streptomyces roseosporus. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.

Daptomycin side effects

It has been observed that Daptomycin causes a calcium-dependent dissipation of the membrane potential (Δ psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (Δ pH) across the membrane (Alborn et al 1991). [source, 2006]
There appears to be a low rate of spontaneous resistance to Daptomycin with limited increases in MIC and relative ease of treatment of resistant isolates (Silverman et al 2001). [source, 2006]
Daptomycin is currently only approved for the treatment of cSSSI caused by susceptible Staphylococcus aureus (MSSA and MRSA), Streptococcus spp. [source, 2006]