Latest research on Darunavir

Darunavir is a protease inhibitor used to treat HIV. It acts on the HIV aspartyl protease which the virus needs to cleave the HIV polyprotein into its functional fragments.

Darunavir side effects

Furthermore, Ethanol exposure significantly decreased the IC50 values of Amprenavir, Darunavir, and nelfinavir but robustly elevated the IC50 of Indinavir and Ritonavir [12, 13], suggesting a differential impact of Ethanol on the binding and bio-transformation of protease inhibitors. [source, 2016]
A minority would replace EFV with raltegravir, Nevirapine, atazanavir or Darunavir, citing potency or concerns about EFV side effects. [source, 2016]
The mean increase in TC in the ritonavir-boosted Darunavir arm from baseline to 48 weeks was clinically significantly greater in the ritonavir-boosted Darunavir arm; a greater mean increase in LDL-C was also observed in the ritonavir-boosted Darunavir arm. [source, 2015]
In the FLAMINGO study, a pre-specified analysis of the mean change from baseline to week 48 in LDL-C demonstrated a significantly lower (p < 0.001) LDL-C increase in the dolutegravir group than in the ritonavir-boosted Darunavir group. [source, 2015]
The mean increase in HDL-C levels from baseline to week 48 was small and comparable between dolutegravir and ritonavir-boosted Darunavir. [source, 2015]
With regard to TC:HDL ratios, the dolutegravir arm showed no increase in the TC:HDL ratio versus an increase of 0.4 in the ritonavir-boosted Darunavir arm from baseline to week 48. [source, 2015]
The mean changes in TG levels increased in the ritonavir-boosted Darunavir group and decreased in the dolutegravir group. [source, 2015]
In the FLAMINGO study, greater increases in TC, LDL-C, and TG levels were observed in the ritonavir-boosted Darunavir arm. [source, 2015]
As Darunavir concentration increased, precursor autoprocessing was suppressed, leading to accumulation of the full length precursor in the cell lysates. [source, 2015]
The 93V variant reduced the overall precursor autoprocessing (Fig 5) but displayed some resistance to Darunavir inhibition because high Darunavir concentrations did not significantly increase accumulation of the full length precursor (Fig 6B). [source, 2015]