Latest research on Doxycycline

A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]

Latest findings

For mild to moderate purulent infections where community-acquired MRSA should be considered, oral sulfamethoxazole/trimethoprim and Doxycycline are recommended, whereas for mild to moderate non-purulent ABSSSIs, oral Clindamycin is an option for treatment.6 [source, 2016]
A single Antibiotic course of oral Doxycycline at a dose of 100 mg, given twice a day, for 3 weeks is the most popular regimen. [source, 2016]
In the first prospective trial of Doxycycline, 20 of the 27 patients were progression free at 2 years; interestingly also 6 CP DNA–negative patients of the 16 treated experienced lymphoma regression. [source, 2016]
Altogether, in 9 studies identified in the literature by Kiesewetter and Raderer, 131 patients were treated with Doxycycline resulting in an ORR of 45%, with CR achieved in 23 patients (18%) and PR achieved by 36 pts. [source, 2016]
An interesting Italian work by Govi et al. showed the efficacy of administration of 500 mg CLARITHROMYCIN, twice a day, for 6-months, in relapsed/refractory EMZL after treatment with Doxycycline. [source, 2016]
Patients who fail to respond to Doxycycline therapy can be successfully salvaged with chemotherapy and/or radiotherapy. [source, 2016]
Oxytetracycline and Doxycycline have both been used in cats to successfully treat M.haemofelis [32] and Lester et al. [33] report a case of successful treatment of a dog infected with M.haemocanis (formerly Haemobartonella canis) with tetracycline [33]. [source, 2016]
We studied the expression of miR-215-5p in HepG2 cells with and without HBV replication by RT-qPCR after 48 h of Doxycycline treatment, and we normalised using miR-24-3p, miR-151a-5p, and miR-425-5p. [source, 2016]
HBV replication was activated by applying Doxycycline (1 µg/ml) to the media. [source, 2016]
The cell lines transfected with the vector containing the HBV genome with and without Doxycycline showed similar amounts of HBsAg in their media, corresponding to the design explained in the section above. [source, 2016]