Latest research on Epirubicin

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. [PubChem]

Latest findings

Based on growth inhibition of 60 human cancer cell lines (NCI60) subjected to Cisplatin, Epirubicine and Capecitabine, in addition to, baseline miRNA expression of the 60 cell lines, a miRNA-based response predictor to the three chemotherapeutic agents was developed. [source, 2016]
All patients had been treated with perioperative chemotherapy with Cisplatin, Epirubicine and Capecitabine. [source, 2016]
To evaluate the correlation between miRNA expression and drug sensitivity, growth inhibition (GI50) vectors of 60 cell lines subjected to Cisplatin, Epirubicine and Capecitabine were downloaded from the DTP web site. [source, 2016]
Hence, a miRNA response profile was developed in which expression levels were correlated to the sensitivity of Cisplatin, Epirubicine and Capecitabine. [source, 2016]
Using the NCI60 cell line panel, sensitivity towards Cisplatin, Epirubicine and Capecitabine was correlated to the baseline miRNA expression of 1756 human miRNAs and other small nucleolar RNAs in the same cell lines. [source, 2016]
In this study, a miRNA profile predictive for sensitivity to Cisplatin, Epirubicine and Capecitabine was developed in 53 patients with gastrooesophageal cancer. [source, 2016]
For the successful prediction of response, profiles for Cisplatin, Epirubicine and Capecitabine were combined. [source, 2016]
When analysing the individual predictors in a multivariate analysis, the Cisplatin and Epirubicine predictors contributed most, while the Capecitabine predictor contributed least (data not shown). [source, 2016]
In this study, miR-200c was included as predictor for response to Epirubicine (negatively correlated). [source, 2016]
In the present study, has-let-7c was negatively correlated with Capecitabine and miR-141 was negatively correlated with Epirubicine. [source, 2016]