Latest research on Epoetin

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Latest findings

Therefore, hyperparathyroidism and Aluminium toxicity were not important causes of Epoetin resistance in our patients. [source, 2001]
reported that hypoalbuminemia is an indicator of both poor nutritional status and presence of the acute phase response and a good predictive parameter of Epoetin hyporesponsiveness [source, 2001]
Therefore, we thought malnutrition expressed by hypoalbuminemia could predict Epoetin hyporesponsiveness. nPNA was a very significant independent variable in multiple linear stepwise regression analysis if CRP was excluded. [source, 2001]
These results strongly indicate that malnutrition plays an important role in Epoetin hyporesponsiveness. [source, 2001]
Therefore, we thought CRP could be a strong indicator of serum albumin level as well as the most significant predictive parameter of Epoetin hyporesponsiveness. [source, 2001]
These consequences may be explained by the fact that inflammatory stimuli elicit the release of various cytokines, such as interleukin-1, interlukin-6, and tumor necrosis factor (TNF) that cause acute phase response and then these cytokines, released during the acute phase response, have been shown to inhibit Epoetin production directly and to act synergistically to inhibit the proliferation and maturation of erythroid precursors [source, 2001]
In conclusion, acute phase response, expressed by high titers of CRP, is the most significant predictive parameter to Epoetin resistance or hyporesponsiveness in patients on CAPD. [source, 2001]
Alternatively, in patients with low probability of response but no correctable cause of failure by these predictive parameters, especially CRP, the dose of Epoetin could be increased early in the course of treatment without waiting for an evaluation of the hematological response after 1–2 months. [source, 2001]