Latest research on Epoetin

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Epoetin dosage

To be included in the maintenance phase, patients should be optimally titrated with the reference Epoetin (stable hemoglobin in the target range with a stable Epoetin dose) for a suitable duration of time. [source, 2016]
ESA doses during the 4 weeks before enrollment were ≤45 000 U/week Epoetin or ≤200 μg/week darbEpoetin. [source, 2015]
Therefore, cumulative changes in the relative levels of N-glycan sialylation and lactosamine repeats due to planned changes (i.e., product evolution) or unknown deviations (i.e., drift) in manufacturing processes of any of the erythropoietins could potentially result in a difference in the required dose for a given patient among various Epoetin products [18]. [source, 2015]
According to the Brazilian Ministry of Health,14 rHuEPO resistance is defined as a persistent anemia (hemoglobin <10–12 g/dL) or the necessity of very high erythropoietin doses of Epoetin alfa (300 IU/kg/week subcutaneously or 450 IU/kg/week intravenously). [source, 2015]
Epoetin alfa should be initiated at a dose of 50–100 IU/kg subcutaneously, one to three times a week. [source, 2015]
Large randomized trials have shown that administration of Epoetin alfa in hepatitis C patients receiving interferon and Ribavirin therapy helped with anemia, resulting in fewer dose reductions, and improved quality of life [7, 8]. [source, 2015]
His Epoetin alfa dose was increased to 60,000 units per week without any substantial response. [source, 2015]
She received a high dose of Epoetin alfa 40,000 units per week for treatment of anemia and developed neutralizing antibodies against Epoetin. [source, 2015]
Mean (SD) weekly dose of biosimilar Epoetin alfa was 7532 (5342) IU, and mean (SD) Hb at baseline was 11.15 (1.17) g/dL. [source, 2015]
Dose of biosimilar Epoetin alfa and Hb level over 18 months by region are illustrated in Fig. 6. [source, 2015]