Latest research on Epoetin

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Epoetin indications

No information was available on the indication (e.g., chronic kidney disease or cancer) for the Epoetin prescription or on drug use during hospitalization. [source, 2016]
The study showed that treatment with Epoetin alfa or Epoetin zeta could be exchanged without any clinically relevant effects (in terms of efficacy, safety, or dosing) [3]. [source, 2016]
In our laboratories, we have used animal models to study the effects of lactosamine extensions and N-glycan sialylation on Epoetin potency. [source, 2015]
Increases in N-glycan branching and sialylation have previously been correlated with increased Epoetin potency, primarily due to their effect on the Epoetin serum half-life [15, 16]. [source, 2015]
Correction of PTA with ESAs (such as EPO and Epoetin beta) has a beneficial effect on slowing post-transplant CKD progression and improving quality of life in renal transplant recipients. [source, 2015]
Calcitriol has a direct effect on erythroid precursors proliferation, as demonstrated both in vitro and in vivo, with a synergistic effect with Epoetin alfa [29]. [source, 2015]
It is rarely seen as an adverse effect of long-term use of recombinant human erythropoietin (Epoetin) due to the production of neutralizing anti Epoetin antibodies. [source, 2015]
From a public health perspective, Epoetin alpha represents a test case for evaluation of the most effective strategies for promoting the use of biosimilars in clinical practice. [source, 2015]
The costs of Epoetin alpha and beta for use in myelodysplastic syndromes are reimbursed by the Regional Health System in Italy, although this is not an approved indication. [source, 2015]
One RCT aimed to determine the effect of Epoetin therapy with and without a home-based individualised exercise programme that incorporated stretching, aerobic and strength resistance training for patients being treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation for MM. [source, 2015]