Latest research on Epoetin

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Epoetin interactions

Of these, 24 patients received an ESA other than DA (Epoetin alfa n=20, Epoetin beta n=1, Epoetin zeta n=3) and, of these, nine patients (Epoetin alfa n=6, Epoetin beta n=1, Epoetin zeta n=2) received another ESA and had baseline and week 9 Hb and QoL assessments. [source, 2016]
An analysis by Więcek et al. [3] evaluated the impact of switching from Epoetin alfa to Epoetin zeta, or vice versa, in patients with chronic kidney disease. [source, 2016]
The study showed that treatment with Epoetin alfa or Epoetin zeta could be exchanged without any clinically relevant effects (in terms of efficacy, safety, or dosing) [3]. [source, 2016]
For example, with Retacrit® (Epoetin zeta; SB309), an EU-approved biosimilar of Eprex®/Erypo® (Epoetin alfa), the extent of glycoforms without an O-linked glycan chain was found to be higher in the biosimilar than in the Epoetin alfa reference product [8]. [source, 2015]
Independent studies, as well as our internal analysis (Table 2) performed after Retacrit® (Epoetin zeta) was approved in the EU, have revealed additional structural differences, including higher levels of lactosamine repeats and lower levels of sialylation relative to Eprex® (Epoetin alfa) [9]. [source, 2015]
Injectables such as Epoetin alfa (EPO), darbEpoetin alfa (DPO), iron, and activated Vitamin D analogs which had previously been reimbursed independently were now included in the bundled payment. [source, 2015]
Although there were some decrease for Capecitabine and Epoetin beta pegol, the decreased values were still higher than those observed in the EPPV period (0–6 month). [source, 2015]
Calcitriol has a direct effect on erythroid precursors proliferation, as demonstrated both in vitro and in vivo, with a synergistic effect with Epoetin alfa [29]. [source, 2015]
Her medications list included Clopidogrel 75 mg, Atorvastatin 40 mg, Bisoprolol 2.5 mg, Amlodipine 10 mg, Omeprazole 20 mg, and Epoetin 4000 units. [source, 2015]
Large randomized trials have shown that administration of Epoetin alfa in hepatitis C patients receiving interferon and Ribavirin therapy helped with anemia, resulting in fewer dose reductions, and improved quality of life [7, 8]. [source, 2015]