Latest research on Epoetin

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Epoetin side effects

This biosimilar has isoforms of higher mass (likely due to increased lactosamine extensions) and additional basic isoforms (due to lower levels of sialylation) in comparison with its reference product, Espo® (Epoetin alfa) [9, 14]. [source, 2015]
Increases in N-glycan branching and sialylation have previously been correlated with increased Epoetin potency, primarily due to their effect on the Epoetin serum half-life [15, 16]. [source, 2015]
Our studies showed that increased lactosamine extensions also increase Epoetin potency and that increased levels of lactosamines could be compensated for by reduced levels of sialylation (unpublished data). [source, 2015]
Although there were some decrease for Capecitabine and Epoetin beta pegol, the decreased values were still higher than those observed in the EPPV period (0–6 month). [source, 2015]
His Epoetin alfa dose was increased to 60,000 units per week without any substantial response. [source, 2015]
It has been proposed that the polysorbate 80 formulation was less stable, causing aggregation of Epoetin alfa molecules especially at increased temperatures, increasing immunogenicity [3]. [source, 2015]
In a secondary analysis of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT), patients with a poor response to darbepoetin alfa had an increased risk of cardiovascular outcomes. [source, 2015]
Epoetin zeta (a biosimilar of Epoetin alpha) prescriptions increased substantially from 2009 to 2013 (from 0 to 18 % in Palermo, from 0 to 21 % in Caserta, from 0 to 24.0 % in the Tuscany region, and from 0 to 38.0 % in Treviso) (see ESM 7). [source, 2015]
To decrease the inflammation and for neuron protection and with the patient's consent for an off-label treatment, darbepoetin alpha (Aranesp) 100 mcg subcutaneous daily for three days, was subsequently added to her medications. [source, 2015]
In a clinical study, in patients with malignant extradural cord compression, a single high dose of erythropoietin (Epoetin alpha 1500IU/ kg IV infusion) before radiotherapy added to Dexamethasone reduced the side effects of radiotherapy on spinal neurons without any major side effects (6). [source, 2015]