Latest research on Eszopiclone

Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent (viz., a sedative) used as a treatment for insomnia. Eszopiclone is the active stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrones. Its main selling point is that it is approved by the U.S. Food and Drug Administration for long-term use, unlike almost all other hypnotic sedatives, which are approved only for the relief of short-term (6-8 weeks) insomnia.

Eszopiclone and alcohol

In a study of the effect of Ethanol on Eszopiclone, there was an additive effect on psychomotor performance for up to four hours after administration of alcohol with Eszopiclone. [source, 2010]
However, Eszopiclone can be deadly if taken with large doses of other CNS depressants (including alcohol) and may have an addictive effect (Anon 2005b). [source, 2007]
Nonetheless, the manufacturer urges caution when prescribing Eszopiclone for patients with history of alcohol or substance abuse and dependence. [source, 2007]