Latest research on Etoposide

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]

Latest findings

The most common chemotherapy regimen was a combination of Cisplatin either with Etoposide or Irinotecan. [source, 2016]
The patient's fever and poor general condition persisted, and under the diagnosis of HLH, Dexamethasone and Etoposide chemotherapy according to the HLH-2004 regimen was started [3]. [source, 2016]
The patient received unrelated hematopoietic stem cell transplantation from a 1-allele mismatched donor after undergoing Busulfan, Etoposide, Cyclophosphamide, and antithymocyte globulin-based conditioning. [source, 2016]
Lung CSCs are known to be resistant to PX [17] and other conventional anticancer drugs such as Cisplatin, Doxorubicin, and Etoposide [15]. [source, 2016]
For refractory thymoma and thymic carcinoma, the NCCN guidelines [12] recommend single-agent or non-platinum-based chemotherapy, such as Etoposide [25], Gemcitabine [26], Paclitaxel [27], Ifosfamide [28], Pemetrexed [29], 5-Fluorouracil (5-FU) and Leucovorin [30], and Octreotide (including long acting-formulation) plus Prednisolone [31]. [source, 2016]
Given his performance status, we considered first-line chemotherapy with Cisplatin and Etoposide. [source, 2016]
In the absence of clinical and radiological findings of pancreatitis, chemotherapy was begun with Cisplatin and Etoposide. [source, 2016]
Cells ectopically expressing wild-type B-Myb (or the S427G variant) showed increased sensitivity to DNA topoisomerase II╬▒ inhibitors (Doxorubicin and Etoposide) in human breast epithelial cell lines. [source, 2016]
Systemic chemotherapies for GEP-NET included Octreotide, VIP (vincristine, Ifosfamide, Cisplatin), XELOX (Capecitabine, Oxaliplatin), EP (Etoposide, Cisplatin), pazopanib, Sunitinib, everolimus, and XELIRI (Capecitabine, Irinotecan). [source, 2016]
The numbers of those who used 5-Fluorouracil (5-FU) and Etoposide together with platinum agents were 30 and 9, respectively. [source, 2016]