Latest research on Exenatide

Exenatide, derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide.

Latest findings

After activation of GLP-1R in cardiomyocytes with the GLP-1 agonists liraglutide and Exenatide, an increase in cyclic ADENOSINE monophosphate promoted membrane protein translocation, resulting in ANP release. [source, 2016]
The current study is a post hoc analysis of a recently randomized controlled clinical trial, where the aim was to determine whether Exenatide improves hemodynamic function in patients with type 2 diabetes and CHF [22]. [source, 2016]
Therefore in the present study we retrospectively analyzed plasma levels for ANP and N-terminal pro-brain natriuretic peptide (NT-proBNP) on the one hand, and hemodynamic parameters, i.e. cardiac index (CI), pulmonary capillary wedge pressure (PCWP), pulmonary artery pressure (PAP), right arterial pressure (RAP), and peripheral resistance, on the other hand, following 6-h Exenatide infusion. [source, 2016]
After an overnight fast, all participants underwent intravenous infusion with glucose (50 mg/mL; 50 mL/h) and insulin [Actrapid, Novo Nordisk, Bagsværd, Denmark, 1–6 U/h to Maintain normoglycemia (4–6 mmol/L)], and Exenatide (0.12 pmol/kg/min) or placebo, provided by Eli Lilly Amylin Alliance (Indianapolis, IN, USA) in a syringe pump device (Ivac Medical Systems, Basingstoke, UK) for 6 h. [source, 2016]
The placebo was the solvent used in the Exenatide infusion. [source, 2016]
In the two-session block-randomization procedure, ten patients received Exenatide on day 1 (Group A) followed by placebo on day 2. [source, 2016]
The remaining 10 patients received placebo on day 1 (Group B) followed by Exenatide on day 2. [source, 2016]
Blood samples for determining plasma ANP, NT-proBNP and Exenatide levels were collected before the start of infusion (baseline) and after 6 h of infusion. [source, 2016]
Exenatide was measured by sandwich immunoassay (Tandem Labs, San Diego, CA, USA). [source, 2016]
Two monoclonal antibodies (capture antibody and detection antibody, Tandem Labs, San Diego, CA, USA) were used to immobilize and detect Exenatide. [source, 2016]