Latest research on FTY720

Fingolimod is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis.

FTY720 and alcohol

However, this compound is also a substrate for SK1, thereby compromising data interpretation. Analogues of the immunosuppressive agent FTY720 (Gilenya) have been prepared using a synthetic route starting with 4-octylphenethyl alcohol and were found to be SK1-selective inhibitors (e.g., RB-005). [source, 2013]