Latest research on FTY720

Fingolimod is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis.

FTY720 side effects

Interestingly, treatment of Kasumi cells with FTY720 increased ceramide and gene expression of ceramide-generating enzymes such as GBA1, DES1, aSMase and nSMase2 (Chen et al., 2014). [source, 2015]
Wallington-Beddoe et al. (2011) demonstrated that FTY720 treatment induced cell death with an increase of LC3-II and reactive oxygen species but independently of caspases. [source, 2015]
Whereas FTY720 treatment decreased the number of malignant cells in a Bcl-2-independent manner and prolonged survival time in a xenograft mouse model of Raji B cells (Liu et al., 2008). [source, 2015]
Because the number of white blood cells and leukocytes were strongly reduced by FTY720 treatment (Fig. 8A,B; P<0.001), renal influx of CD3-positive T cells was significantly reduced at 12 weeks (Fig. 4E,F; P<0.05). [source, 2015]
At the mRNA level, FTY720 also could not prevent the increase in collagen I (α1), collagen III (α1), TGF-β1, MCP-1/CCL2 and osteopontin, although significantly prevented the increase of VCAM-1 mRNA expression (Fig. 5). [source, 2015]
Interestingly, although FTY720 significantly prevented the increase of α-SMA-positive myofibroblasts, it was not effective in decreasing collagen III deposition, although it significantly reduced tubulointerstitial fibrosis (PAS scoring). [source, 2015]
To resolve this, we treated dermatitis mice with the cell egress blockers FTY720 or 4-deoxypyridoxine (DOP), which retain cells in BM for 24 h2526, continuously from one day after transplantation of Luc-Tg Lin− cells, and monitored the increase in the luminescence signal in the inflamed ear (Fig. 4a). [source, 2015]
Another intriguing point about the dynamics of infused Lin− cells is that the progenies undergo in situ expansion in the inflamed skin, as confirmed by the increase in number of the progenies and the presence of BrdU-incorporating cells at the inflamed sites even following treatment with the BM-egress blockers FTY720 and DOP. [source, 2015]
In Ph1 ALL progenitors, the inhibition of PP2A activity occurs in a SET-dependent manner and the reactivation of the PP2A by FTY720 causes growth inhibition and induction of caspase-dependent apoptosis toward p190 down-regulation (38). [source, 2015]
In FTY720 treated animals, the ratio of lamina propria (LP) CD8β+ cells/intraepithelial (IEP) CD8β+ cells significantly decreased (p < 0.0001 by a Student’s t test) from 2.03±0.097 (mean ± SEM) to 0.53±0.059 (Fig. 2d, e). [source, 2015]