Latest research on Finasteride

An orally active testosterone 5-alpha-reductase inhibitor. It is used as a surgical alternative for treatment of benign prostatic hyperplasia. [PubChem]

Latest findings

Finasteride is chemically considered a synthetic 4-azasteroid drug. [source, 2016]
The aim of this study was to develop freeze-dried Finasteride NPs from aqueous nanosuspension formulation, characterized by enhanced drug solubility and dissolution rate, with subsequent loading into hard gelatin capsules. [source, 2016]
Finasteride was a kind gift from SAJA Pharmaceuticals (Jeddah, Saudi Arabia). [source, 2016]
To prepare an optimized Finasteride nanosuspension formulation characterized by smaller particle size and higher solubility enhancement values of 677.214 nm and 155.383%, respectively, the optimize desirability was identified and the composition of the optimized formulation was suggested to contain 0.66867, 1.54226, 17,660, and 10.5844 of X1, X2, X3, and X4, respectively. [source, 2016]
Figure 3 illustrates the TEM image of the optimized Finasteride nanosuspension formulation. [source, 2016]
Mixing the drug with PVA as a physical mixture or the optimum Finasteride formulation did not affect the characteristic drug-melting endotherm as illustrated in Figure 4. [source, 2016]
Finasteride IR spectra showed characteristic peaks at 1,666 and 1,598 cm−1 corresponding to the two amide groups. [source, 2016]
Nagalaxmi et al32 demonstrated three functional groups: amide, ketone, and alkyl groups after Finasteride FTIR scanning. [source, 2016]
Finasteride physical mixture with PVP and the optimum drug micronized formulation did not interfere with the characteristic drug peaks as shown in Figure 5, which confirms the compatibility. [source, 2016]
X-ray powder diffraction (XRPD) was performed to investigate the physical state of Finasteride in the pure drug state and also in the optimized freeze-dried NPs formulation. [source, 2016]