Latest research on Fluticasone

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone proprionate is marketed under several different brand names such as Flonase®. Fluticasone propionate is also available as a combination product of azelastine hydrochloride and fluticasone propionate called Dymista™. Dymista™ is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.

Latest findings

Dr Tralau-Stewart and coworkers have demonstrated inhibition in an ozone-induced model of COPD with the p38 kinase inhibitor SB 239063; inhibition of neutrophilia in an lipopolysaccharide-driven model with GW 311616, an elastase inhibitor; and, in a multi-dose lipopolysaccharide model, they demonstrated efficacy of the steroid, Fluticasone. [source, 2002]
She began to take asthma medications, including sustained-release Theophylline (200 mg twice a day), pranlukast hydrate (112.5 mg twice a day), Salmeterol xinafoate inhaler (25 mg twice a day) and Fluticasone propionate (250 mg twice a day). [source, 2002]
At two months after discharge, her asthma has been well controlled with regular medications, including pranlukast hydrate (112.5 mg twice a day), Salmeterol xinafoate inhaler (25 mg twice a day) and Fluticasone propionate (250 mg twice a day), without adverse effects. [source, 2002]
To further determine the effect of glucocorticoid treatment, a group of asthmatic subjects were treated with inhaled Fluticasone (1,760 μg/d) for 30 d before an initial bronchoscopy/BAL; Fluticasone was then discontinued and subjects were monitored for an additional 6 wk or until peak expiratory flow had decreased by 25% or forced expiratory volume in 1 s by 15% at which time a second bronchoscopy/BAL was performed. [source, 2001]
J Bishara (Southampton General Hospital, UK) studied the in vitro effects of Fluticasone and Salmeterol [10] and M Mikami (Tokyo Metropolitan Hiro-o General Hospital, Japan) studied the mucoactive agent s-carboxymethyl cysteine [11]. [source, 2001]
Furthermore, animal models have been useful in the development of better bronchodilator drugs such as long-acting β2-adrenoceptor agonists, including Salmeterol and formoterol, better glucocorticosteroids (for example Fluticasone) and in the development of leukotriene antagonists. [source, 2000]
Asthmatic subjects were treated with inhaled triamcinolone (1,600 μg/d) or Fluticasone (1,760 μg/d) for 30 d before the first endobronchial biopsy. [source, 1998]
A ciclesonide dose of 320 mcg is equivalent to 440 mcg Fluticasone, the most potent inhaled corticosteroid [20-22]. [source]