Latest research on Folate

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Latest findings

The intervention provided 1g DHA and 160mg EPA per day in addition to Ginkgo biloba, PS, α-tocopherol, Folic acid, and Vitamin B12 (See Supplementary Table S1). [source, 2016]
Previous studies with either omega-3 PUFAs (30) or Folic acid and Vitamin B12 (31) supplementation have failed to provide evidence of beneficial effects on information processing speed in older adults. [source, 2016]
Vitamin B stock was 500 mg Folic acid (Thermo Fisher, BP2519) dissolved in 167 ml 20% Ethanol, aliquoted and frozen at -20°C protected from light. [source, 2016]
These major risk factors include maternal exposure to tobacco smoke, alcohol, and corticosteroids; Folic acid deficiency; zinc deficiency; and maternal grief. [source, 2016]
Although folic acid deficiency has been found to cause cleft palate in animal models, including a protective effect of folic acid supplements against trans-retinoic acid-induced cleft palate in mouse models (Yao et al., 2011), data on Folate use and risk of cleft palate in humans have been inconclusive. [source, 2016]
Several clinical studies on maternal use of Folate and risk of CPO showed no significant association between the two (Johnson and Little, 2008; Little et al., 2008; Li et al., 2012; Butali et al., 2013a), with one study reporting an odds ratio of 0.95 with folic acid use (Johnson and Little, 2008). [source, 2016]
However, these inconsistencies may partially be due to differences in methods of ascertainment for folic acid intake, as folic acid is available through dietary Folate, folic acid supplements, or multivitamins with folic acid (Li et al., 2012). [source, 2016]
Some studies differentiate between these different forms while others do not, which may cause inconsistencies in the data if the dose of Folic acid varies greatly between women. [source, 2016]
Additionally, even though there has been a reported decrease in oral clefts in North America since the mandatory fortification of grains with Folic acid in the late 1990's (Parker et al., 2010; Saad et al., 2014), this decline is seen only in CL/P, while CPO rates have remained fairly constant (Johnson and Little, 2008). [source, 2016]
For both syndromic and non-syndromic CPO, these odds ratios are more significant than those of smoking, Folic acid deficiency, and maternal alcohol use. [source, 2016]