Latest research on GnRH

Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.

Latest findings

GnRH, a hormone produced by specific neurons in the hypothalamus, triggers the release of LH from the pituitary gland. [source, 2016]
To further investigate whether reduced testosterone in Prl7d1 transgenic mice was associated with the disruption of GnRH and LH levels, serum GnRH and LH levels were analyzed by ELISA. [source, 2016]
As shown in Figure 4C,D, there were no significant differences of serum GnRH and LH levels between the wild-type and Prl7d1 transgenic mice, which demonstrated that PRL7D1 overexpression exerted its inhibitory effect on testosterone synthesis not through directly affecting GnRH or LH levels. [source, 2016]
Decreased testosterone levels are thought to arise from disturbed steroidogenesis in Leydig cells or reduced hypothalamic GnRH or pituitary LH stimuli [25,26]. [source, 2016]
Serum GnRH and LH levels were unchanged in transgenic mice, indicating that PRL7D1 overexpression had no apparent effect on the GnRH and LH levels, and the reduced testosterone production was not through alterations in GnRH or LH signaling. [source, 2016]
ELISA kits for testosterone, GnRH and LH were purchased from USCN (Wuhan, China). [source, 2016]
Serum testosterone, LH and GnRH levels and intratesticular testosterone levels from testis homogenates were measured using an ELISA kit according to the manufacturer’s instructions. [source, 2016]
The testosterone, LH or GnRH value of each sample was extrapolated from a standard curve prepared with known concentrations of testosterone, LH or GnRH. [source, 2016]
Gonadotropin-releasing hormone (GnRH) is the primary hormone associated with reproduction; GnRH is known to exert its actions largely through two related Gq/11 protein receptors [25]. [source, 2016]
The interaction between GnRH and its cognate type I receptor (GnRHR) in the pituitary results in the activation of Gq, PLC-β, phospholipase A2 (PLA2), and phospholipase D (PLD) [2]. [source, 2016]