Latest research on Goserelin

Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.

Latest findings

These include gonadotropin releasing hormone (GnRH) analogues such as buserelin and, Goserelin, selective estrogen receptor modulators (SERM) such as Raloxifene, selective progesterone receptor modulators (SPRM) such as ulipristal, and progesterone antagonists such as mifepristone [18–21]. [source, 2016]
Patients in the radiotherapy series were treated by brachytherapy (BT), EBRT, BT + EBRT, or salvage EBRT with or without neoadjuvant/adjuvant ADT (more than 3 months) by surgical castration or medical castration using a luteinizing hormone-releasing hormone agonist (Goserelin acetate or Leuprorelin acetate) and/or an antiandrogen agent (Bicalutamide, Flutamide, or chlormadinone acetate). [source, 2015]
Adjuvant hormone therapy consisted of Tamoxifen in all but one patient who received Goserelin. [source, 2015]
Patients received the following treatments: Letrozole 2.5 mg orally daily as a monotherapy or with Leuprolide Acetate or triptorelin acetate given intramuscularly at 3.75 mg every 28 days, CPA 100 mg twice a day as a monotherapy or combined with buserelin administered subcutaneously at 1500 μg daily in three doses during the first week and then reduced to 600 μg a day or Goserelin administered at 3.6 mg subcutaneously every 28 days, Exemestane 25 mg once daily or Anastrozole 1 mg once a day. [source, 2015]
In a meta-analysis done by Sasse et al., androgen suppression with Goserelin was found to have better overall survival and disease-free survival when compared to radiotherapy alone in patients at high risk of recurrence or metastases. [source, 2015]
Premenopausal women received Goserelin. [source, 2015]
His symptoms persisted despite these interventions and 1 week later the decision was made to discontinue the estrogen patches and switch his therapy to an LHRH analog (Goserelin). [source, 2015]
Ovoprotective drugs that have shown promise in animal studies include FTY720 (protects against radiation ovotoxicity), AS101 (protects against Cyclophosphamide), Imatinib and Mesna (protect against Cisplatin), bortezomib and Dexra (protect against DXR), and Tamoxifen (protects against Cyclophosphamide in vivo, DXR in vitro), and Goserelin (protects against multi-drug breast cancer chemotherapy) [23,27,66,73–78]. [source, 2015]
Indeed, peptides such as Goserelin, Octreotide, and lanreotide are commonly used anticancer drugs [38]. [source, 2015]
Endocrine therapy included either Tamoxifen, or a combination of Tamoxifen and Goserelin acetate. [source, 2015]