Latest research on Herceptin

A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture.*

Herceptin dosage

trastuzumab emtansine (T-DM1) is an ADC consisting of the anti-HER2 mAb trastuzumab (Herceptin) and the maytansinoid DM1 has been administered safely at therapeutically effective doses, despite HER2 being expressed on some normal tissues [95–98]. [source, 2015]
The chemo-regimen used at our institution from 2002 to 2006 consisted of two to four cycles of dose-dense AC (Doxorubicin and Cyclophosphamide, one cycle every 2 weeks) followed by taxane regimen (TCa ± H, Paclitaxel and Carboplatin with Herceptin for HER2/neu-positive patients). [source, 2015]
She received a total of 25 doses of Herceptin. [source, 2015]
The rats in the H+NRG group were subjected not only to irradiation and administration of rhNRG-1β at the same dose as in the NRG group but also to intravenous injection of Herceptin (15 μg/kg; Roche, USA) 1 h before rhNRG-1β injection. [source, 2015]
The objective of this study was to actually determine whether Herceptin diluted for a patient dose was stable and could be used for another patient or dose administration in an effort to reduce healthcare costs. [source, 2015]
In addition, the required clinical dose of the BsAb is extremely low at only 1/500 of that required for Herceptin (20). [source, 2015]
Herceptin dosages were dependent on the weight of the patient: Herceptin dose for the first cycle (mg/kg) = 6 mg × weight of patient (kg); Herceptin dosage for the second to final cycle (mg/kg) = 4 mg × weight of the patient (kg), each cycle lasts for 21 days and the overall treatment lasts for a year. [source, 2015]
In vitro proliferative dose responses to combinations of MM-111, Herceptin, lapatinib, MK2206, and GSK112012 were assessed in seven HER2+ cell lines, in the presence and absence of 5nM exogenous HRG ligand. [source, 2015]
To study the effect of resveratrol and didox on the cytotoxic profile of Herceptin, the dose response curve of Herceptin alone was assessed relative to its combination with resveratrol or didox in two different breast cancer cell lines; MCF-7 and T47D (Table 1). [source, 2015]
In T47D breast cancer cell line, steeping dose response curve was observed upon treatment with Herceptin until resistant fraction of 6.26 ± 0.51% (Fig. 1a,c). [source, 2015]