Latest research on Humalog

Insulin lispro is a recombinant human insulin analogue produced in a specialized laboratory strain of Escherischia coli. Plasmid DNA transfected into the bacteria encodes for an analogue of human insulin that has a lysine at residuce B28 and proline at B29; these residues are reversed in endogenous human insulin. Reversal of these amino acid residues produces a rapid-acting insulin analogue. FDA approved on 1996.

Latest findings

Following insertion of catheters, target plasma glucose levels at each stage of the clamp were achieved by titrating the rate of infusion of a 20% dextrose solution while maintaining constant rate of insulin (A 1:1 dilution of 60U Humalog in 60 mL of 0.9% saline solution) at 60 mU m−2 min−1. [source, 2016]
During hospitalization, patients in CSII alone group received insulin Aspart (NovoRapid, Novo Nordisk, Bagsværd, Denmark) or insulin lispro (Humalog, Eli Lilly, USA) with an insulin pump (MiniMed 712, Medtronic, Northridge, CA) as CSII therapy, while the CSII + Lira group received liraglutide (Victoza, Novo Nordisk, Bagsvaerd, Denmark) 0.6 mg per day in addition to aforementioned CSII regimen. [source, 2016]
For glucose- and insulin-tolerance tests, 14-3-3ζKO or 14-3-3ζTAP male mice AT 10 and 25 weeks or 9 and 52 weeks, respectively, were fasted for 6 h, followed by i.p. injection of 2 g kg−1 glucose or 1.5 U kg−1 Humalog insulin (Eli Lilly, Indianapolis, IN), respectively. [source, 2015]
Medication history included Amlodipine, Aspirin, Calcium carbonate, Synthroid, Pioglitazone, Humalog, Glucovance, Crestor, Januvia, and Lisinopril. [source, 2015]
For ITT, mice fasted for 4 h were challenged with an i.p. injection of insulin lispro (Humalog, Lilly) at a dose of 0.75 (for chow-fed mice) or 1.5 U kg−1 (for HFD-fed mice). [source, 2015]
For insulin signalling experiments, mice fasted overnight were injected i.p. with insulin lispro (5 U kg−1, Humalog) or PBS. [source, 2015]
Stimulations included: insulin neutral protamine Hagedorn (NPH) (Insuman Basal, Sanofi Aventis, Paris, France), insulin glargine (Lantus, Sanofi Aventis), first metabolite of glargine (M1, Sanofi Aventis), second metabolite of glargine (M2, Sanofi Aventis), glulisine (Apidra, Sanofi Aventis), lispro (Humalog, Eli Lilly, Indianapolis, IN, USA), insulin X10 (not marketed, Novo Nordisk, Bagsvaerd, Denmark), Aspart (B28Asp, Novo Nordisk), detemir (Levemir, Novo Nordisk) and insulin-like growth factor 1 (IGF1) (Increlex, Ipsen, Basking Ridge, NJ, USA). [source, 2015]
She is treated with Humalog 75/25, 31 units before breakfast and 27 units before dinner. [source, 2015]
Insulin glucose tolerance test (IGTT) was performed 10 days prior to decapitation (on the 140th day of experiment); to do this, D-glucose (2 g/kg, i.p.) and insulin (Humalog, 0.8 IU/kg b. w., s.c.) were administered simultaneously. [source, 2015]
Mice were injected intraperitoneally with glucose (Vps15f/f, Vps15 LKO, iLIRKO, chow-fed wild-type and HFD-fed wild-type mice—2 g kg−1, ob/ob—1 g kg−1), Humalog insulin (1 μ kg−1) or pyruvate (2 g kg−1), and blood was collected from the tail vein for determination of glucose levels at different time points using Glucotrend glucometer (Roche Diagnostics). [source, 2015]