Latest research on IGF-1

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.

Latest findings

This pathway also involves the genes IGF1 and IGFR1, both are associated with haplotypes influencing body size between dog breeds [16, 58], suggesting that this pathway may have been repeatedly targeted by selection for body size during dog domestication. [source, 2016]
Insulin-like growth factor (IGF)-1 and other members of the IGF-1 pathway have been associated with development, progression, and metastasis of several cancers [1, 2]. [source, 2016]
Additionally, epidemiologic studies have shown a relation between high circulating IGF-1 levels, breast density [3], and risk of breast cancer (BC) [4]. [source, 2016]
Increased IGF-1 levels are associated with an elevated BC mortality [5] and with inherent resistance to anti-tumor treatments in preclinical models [6–9]. [source, 2016]
Furthermore, the IGF-1 receptor (IGF-1R), a transmembrane TYROSINE kinase, is frequently upregulated in BC [10, 11]. [source, 2016]
The biological activity of IGF-1 and IGF-2 depends on binding with the insulin-like growth factor binding proteins (IGF-BPs), mainly IGF-BP3 [12, 13]. [source, 2016]
Moreover, genes encoding members of the IGF-1 pathway are known to harbor several single nucleotide polymorphisms (SNPs) that influence the activity of the pathway. [source, 2016]
SNPs associated with IGF-1 and IGF-BP3 plasma levels and breast density are described [19, 20] as well as SNPs associated with therapy resistance and outcome [21, 22]. [source, 2016]
Moreover, we aim to identify SNPs, which have been described to influence the activity of the IGF-1 pathway, to predict chemotherapy efficacy in this cohort. [source, 2016]
To select relevant SNPs in the IGF-1 pathway, a PubMed search with the keywords “IGF-1”, “IGF-2”, “IGF-BP3”, “IGF-1R”, “single nucleotide polymorphism”, “breast cancer”, and/or “clinical outcome” was conducted in July 2013. [source, 2016]