Latest research on Ibuprofen

Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Latest findings

Non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen and Indomethacin are effective in reducing the pain in endodontic treatments and are commonly prescribed for this reason [6]. [source, 2016]
Rudimentary investigations prove that premedication with NSAIDs such as Flurbiprofen, Ibuprofen, Tenoxicam, or rofecoxib can decrease the amount of post-operative pain more efficiently than placebo [10-12]. [source, 2016]
Gopikrishna et al. [11] showed that single dose prophylactic prescription of rofecoxib (50 mg) or Ibuprofen tablet (600 mg) significantly relieves the postoperative endodontic pain. [source, 2016]
In another study by Arslan et al. [12] prophylactic prescription of Ibuprofen (200 mg) and Tenoxicam (20 mg) significantly reduced the postoperative endodontic pain. [source, 2016]
However, Attar et al. [14] has shown that there was no significant difference in postoperative endodontic pain between patients who took Ibuprofen tablet, Ibuprofen liquigel (400 mg) and placebo, preoperatively. [source, 2016]
Likewise Parirokh et al. [16] demonstrated the effectiveness of Indomethacin and Ibuprofen on increasing the depth of inferior alveolar nerve block. [source, 2016]
However, many studies have evaluated the effectiveness of prophylactic premedication with Ibuprofen on postoperative endodontic treatment [11, 12, 14]. [source, 2016]
No study has compared the effectiveness of prophylactic premedication with Ibuprofen and Indomethacin on pain relieve after endodontic procedures. [source, 2016]
Therefore the aim of this clinical trial was to compare the effects of premedication with Indomethacin and Ibuprofen on postoperative endodontic pain. [source, 2016]
With a double blind design, medicines were administered in all groups 1 h before endodontic procedure; group A [400 mg Ibuprofen tablet (Hakim Pharmacy Co, Tehran, Iran)], group B [25 mg Indomethacin (Hakim Pharmacy Co, Tehran, Iran) and group C (placebo, starch powder) which were all prepared in similar capsules. [source, 2016]